Pollex T, Furlong EE (2017)Mol Cell, 66(4):439-441.Read it on: Mol Cell | DOI:10.1016/j.molcel.2017.05.005
Although H3K4me1 is a pervasive “mark” of enhancers, its functional requirement for enhancer activity remains unclear. In this issue of Molecular Cell, Dorighi et al. (2017) show that in some contexts, the methyltransferase complex, rather than the H3K4me1 mark, is required for gene expression.